Thus, the interaction between fibroblasts and epithelial cells also plays a pivotal role in BPH progression and other prostatic disease.7 Our previous study found that the expression of LC3A/B and Beclin‐1 was significantly increased in BPH tissues compared with that in control group prostate tissue.8 Autophagy is a highly conserved lysosomal pathway in eukaryotes that functions to recycle and degrade various cellular components.9 Autophagy often exerts cytoprotective functions to sustain the re‐establishment of the cell status. The gene discussed is BECN1; the disease is benign prostatic hyperplasia.