Insulin‐like growth factor‐1 (IGF‐1) is one of the insulin‐like proteins that can affect cell differentiation, proliferation, apoptosis, and organismal growth and development.18 Epidemiological studies have suggested that elevated levels of IGF‐1 are associated with an increased risk of BPH.19 IGF‐1 is also a key factor that mediates the transduction of prostate stromal‐epithelial cell signalling. Here, IGF1 is linked to benign prostatic hyperplasia.