In patients with malignant tumors, overproduction of circulating cytokines such as interleukin‐6, tumor necrosis factor alpha and CRP has also been shown to play a key role in the induction of chronic inflammation.29, 30 In addition, many types of inflammatory factor receptors are detected on the surface of red blood cells, and it is speculated that red blood cells are involved in the inflammatory process. The gene discussed is TNF; the disease is cancer.