In order to investigate the translational relevance of the IL‐8/CXCR1 axis to the clinic, IL‐8 and CXCR1 protein expression was evaluated in 255 ccRCC patients using tissue microarrays (Table S5 and see supplemental material, Supplementary material and methods). Here, CXCL8 is linked to nonpapillary renal cell carcinoma.