The organization of the aortic ECM is very crucial since it is needed for maintaining tensile strength as well as stiffness of the aorta.[15,16,24] Any alterations in the composition of the ECM including collagen and elastin have tremendous effects on the normal function of the ECM which might be involved in the formation of aneurysms or dissections.[25–28] Therefore the present study aimed at analysing the ECM structure/amount/quality of control and aneurysmal/dissection tissue in its native form as well as after decellularization. The gene discussed is ELN; the disease is aneurysm.