Polymorphisms of matrix metalloproteinase (MMP)8 rs11225394 and MMP9 rs3787268 are closely related to BC risk in the Chinese Han population.13 The XPG (rs1047768 T > C) mutation may play an important role in the reduction of progression‐free survival and can be used as a predictor of poor prognosis in BC.14 Therefore, bioinformatics analysis of the prognosis of mutated genes and screening for specific SNP mutated genes can provide clinicians with new tools for treating patients and predicting prognosis. The gene discussed is MMP8; the disease is breast cancer.