PTPN22 and autoimmune disease: Notably, PTPN22 as well as NFKB1 genes are strongly associated with multiple autoimmune diseases,78, 79 and our findings that PPP1R11 modulates T cell resistance to Tregs allow to speculate that in addition to their direct effects in immune cells, susceptibility of T cells to Tregs involving these genes may add to their role in autoimmune disease.