There is a report concerning insulin-treated diabetes mellitus (ITDM) patients have greater ADP-induced platelet aggregation, and the cardiovascular event might have increased in ITDM patients.[28] However, there were no significant differences in clinical outcomes between the clopidogrel and the prasugrel/ticagrelor group according to each diabetes medications in subgroup analysis (Supplement table). Here, INS is linked to diabetes mellitus.