For this purpose, we aimed to evaluate the association of polymorphisms in the STAT4 (rs7574865), TRAF3IP2 (rs33980500), HCP5 (rs3099844), and IL10 (rs1800872 and rs3024505) genes with SS susceptibility and to elucidate their role in the modulation of clinical and laboratory features in a cohort of Italian patients. Here, STAT4 is linked to synovial sarcoma.