Interestingly, the variant allele of HCP5 SNP is associated with a higher risk to develop anti-SSA (OR = 3.07, P = 0.006), anti-SSB (OR = 2.66, P = 0.005), rheumatoid factor (OR = 2.17, P = 0.028), hypergammaglobulinemia (OR = 2.54, P = 0.007), leukopenia (OR = 2.1, P = 0.047), and lymphoma (OR = 7.23, P = 0.002). Here, CALR is linked to Decreased total leukocyte count.