While the infection-induced increase of CD8+ T cells producing IFN-γ was not strain related, TNF-α splenic CD8+ T cell secretion potential of SV/129 mice was significantly higher than the one of CD8+ T cells from both BALB/c and C57BL/6 animals (Figure 5B; p ≤ 0.0001). The gene discussed is TNF; the disease is infection.