Given the characteristic metabolic alterations induced in ccRCC, we next investigated the effect of combination therapy of Compound A or cabozantinib with metabolic inhibition by 6AN, an inhibitor of the rate-limiting PPP intermediate G6PD (FPM 945.06 and 1241.78 in SKRC7 and SKRC17, respectively). Here, G6PD is linked to nonpapillary renal cell carcinoma.