Compared with wild-type MYD88, MYD88L265P leads to enhanced phosphorylation of IRAK, activation of NF-κB, and JAK-STAT3 signaling, and increased secretion of interleukin 6 (IL-6), interleukin 10 (IL-10), and interferon-β promoting the survival of ABC DLBCL cell lines. Here, MYD88 is linked to diffuse large B-cell lymphoma.