The biological effect of tonic BCR signaling in GCB DLBCL is highly dependent on AKT activation, as tonic BCR signaling triggers AKT activation and forced AKT activation can rescue GCB DLBCL cells from depletion of the BCR or tonic BCR signaling mediators SYK and CD19 (21). Here, AKT1 is linked to diffuse large B-cell lymphoma.