We also observed that compared to separately knocked-down or overexpressed ILF2 and CREB, simultaneously knocked-down or overexpressed ILF2 and CREB more obviously inhibited or stimulated the proliferation and colony formation, whereas they stimulated or inhibited the caspase 3/7 activity of liver cancer cells (Figures 3(c)–3(h)). The gene discussed is CREB1; the disease is liver cancer.