CXCL12 and neoplasm: Like in human skin, fat grafted into the irradiated skin of mice improves the healing of radiation-induced ulcers, reduces skin hyperpigmentation, and attenuates dermal thickness and collagen deposition.20,26,40–42 The fat grafts also increase skin vascularity, normalize the architecture of skin microvasculature, and enhance the expression of vasculogenic factors including vascular endothelial growth factor (VEGF) and stromal cell-derived factor 1 (SDF-1).20,26,40,41