Compared with previous research, this study first systematically investigates the hypoglycemic and renal protective effects of SCU in db/db mice and confirms that SCU have effective actions against DM by controlling blood glucose concentration and insulin secretion and mitigating abnormal lipid accumulation and renal inflammation at least partially via modulation of the Nrf2/HO-1 signaling pathway. This evidence concerns the gene NFE2L2 and diabetes mellitus.