Alcohol intoxication and withdrawal affect numerous neurotransmitters including gamma-aminobutyric acid, dopamine, N-methyl-d-aspartate, adrenocorticotropic hormone, and endorphins.10 Patients who use alcohol are at risk for myriad psychiatric problems including depression, anxiety, hallucinations, impaired judgment, and impaired cognition.10 In addition, the concurrent use of alcohol with prescription medications can lead to numerous adverse effects. This evidence concerns the gene POMC and major depressive disorder.