A recent study revealed that ANXA2 enhances the progression of the HCC cell via remodeling the cell movement [14], which to some extent supports the result of our experiment and hypothesis that ANXA2 mRNA and ANXA2P2 may interact directly or indirectly to promote tumor cell invasion or metastasis through remodeling the HCC cell movement. Here, ANXA2 is linked to hepatocellular carcinoma.