TRPM8 and melanoma: Moreover, previous study has reported that TRPA1 and TRPM8 were expressed in human melanoma [15, 32]; our data showed that TRPA1 protein increased in all four melanoma cells (Figure 1(a)(v)), and TRPM8 protein level was increased in A375 and A2058 cells compared to melanocytes (Figure 1(a)(vi)).