Specifically, TRPV1 and TRPV3 transcripts showed very weak expression both in human melanocytes and melanoma cells (Figures 1(b)(i) & 1(b)(iii)) which exhibited good concordance with protein distribution, while TRPV2 was markedly decreased in all four melanoma cell lines compared to melanocytes (Figure 1(b)(ii)), which was discordant with our protein expression results. The gene discussed is TRPV3; the disease is melanoma.