MMP1 and lip and oral cavity carcinoma: Yen et al reported MMP-1 and MMP-10 as potential oral cancer marker by using AUCs of relative gene expression as 0.715, 0.727 and 0.513 for MMP-1, MMP-10 and MMP-12, respectively.21 While in our findings, MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80.0% and 78.9%, respectively in serum.