The authors hypothesized that the increase in vaspin levels in serum and adipose tissue could be due to the compensatory response to insulin resistance.3,24 In uremic patients without diabetes, insulin resistance was found when the GFR fell below 50 ml/min.10,25 In our study, the patients in the CKD group were those with stage 3-5 renal insufficiency due to non-diabetic causes. This evidence concerns the gene SERPINA12 and Renal insufficiency.