NPPB and cardiac hypertrophy: In aortic valve patients the left ventricle increases the secretion of NT-proBNP level due to increase in pressure overload.11 Several other studies have illustrated that NT-proBNP is associated with functional status and progression of cardiac hypertrophy.2 The diagnostic utility data of NT-proBNP regarding left ventricle hypertrophy due to aortic regurgitation is very limited but it is demonstrated that NT-proBNP is increased during disease severity.