NPPB and left ventricular hypertrophy: In the present investigations we have found a significant high level of NT-proBNP expression in all the three pathological conditions of stenosis and regurgitation of aortic valve with left ventricle hypertrophy justifying the previous data.15 In addition, the significant high level of NT-proBNP also showed increase in severity of left ventricular hypertrophy in all the disease groups.