Testosterone (T) and dihydrotestosterone (DHT) are synthesized in the skin and bind to the androgen receptor.4 Clinical studies support the role of androgenic hormones in acne pathogenesis and cite the approximation of acne onset with surge of dihydroepiandrosterone sulphate (DHEA-S), acne in congenital adrenal hyperplasia (CAH), sudden onset acne, androgens administration leading to acne and improvement by androgen receptor blockers. This evidence concerns the gene AR and congenital adrenal hyperplasia.