Disturbing influence in these administrative impacts prompts to insulin resistance and cardiovascular diseases.1 Ramadan fasting is associated with alteration in classically activated macrophage regulation/signaling and increase macrophage function and of pro-inflammatory cytokines and immune cells in healthy subjects.2,3 Adiponectin with its immune function and anti-inflammatory action can help this beneficial balance of cytokines during the fasting.4 Here, ADIPOQ is linked to Insulin resistance.