Fms like tyrosine kinase 3 (FLT-3) is involved in normal haematopoiesis regulating differentiation, proliferation and survival of hematopoietic progenitor cells.8 Internal tandem duplications of the juxtamembrane domain result in constitutive activation of the FLT-3 receptor tyrosine kinase and in AML are a prognostic indicator associated with adverse disease outcome.9 This evidence concerns the gene FLT3 and acute myeloid leukemia.