MTOR and tuberous sclerosis: The increased mTOR pathway activity is a central pathogenic mechanism shared by FXS, aging, and several other neurological disorders such as autism and tuberous sclerosis, evidenced by reproducible results from yeast to mammalian animal models (Fabrizio et al., 2001; Jia et al., 2004; Johnson et al., 2013; Ebrahimi-Fakhari and Sahin, 2015; Kilincaslan et al., 2017).