This is likely due to the sample size constraints imposed by WGS which limits the ability to detect significant associations for low frequency variants such as DAF −198 C > G. This SNP had a frequency of 0.13 among the OP-MG subjects in this study (p = 0.119) which is comparable to the statistically significant association previously reported using a larger sample size (0.12, p = 0.001) (Heckmann et al., 2010), albeit with an overlap of two OP-MG samples between the two studies. Here, CD55 is linked to myasthenia gravis.