Their frequency was also determined in a validation sample (n = 28) which confirmed the association of these variants with OP-MG: PEF1 rs16834631 0.57 in OP-MG vs. 0.16 in control MG (p = 0.001) and FAM92A1 rs7816955 0.47 in OP-MG vs. 0.18 in control MG (p = 0.021; Figure 3A). The gene discussed is PEF1; the disease is myasthenia gravis.