BET proteins have been implicated in the regulation of some cancer-related genes (Delmore et al., 2011): for example, BRD4 recruits the positive transcription elongation factor complex (P-TEFb) to acetylated chromatin, leading to the transcriptional initiation and elongation of genes controlling cell proliferation (Yang et al., 2005); and BRD9 facilitates maintenance of the leukemic phenotype (Bakshi et al., 2010; Shi et al., 2013) as a component of the SWItch/Sucrose Non-Fermentable (SWI-SNF) chromatin-remodeling complex (Hohmann et al., 2016). Here, DNER is linked to cancer.