MYC and acute myeloid leukemia: demonstrated the use of a small-molecule inhibitor, JQ1, to inhibit BET proteins as regulatory factors for c-Myc (Delmore et al., 2011), which has been implicated in the pathogenesis of many cancers (Miller et al., 2012), including acute myeloid leukemia, in which c-Myc tends to be upregulated (Luo, 2005).