IDH1 and acute myeloid leukemia: In 2018, the Food and Drug Administration (FDA) approved ivosidenib (Tibsovo®), an inhibitor of IDH1/2HG production, for adult AML patients with the IDH1 mutation (Dhillon, 2018), following clinical trials, which indicated that ivosidenib induced remissions and improved patient outcomes (DiNardo et al., 2018).