PML and acute promyelocytic leukemia: have identified DNA methylation and histone acetylation signatures discriminative of high-risk acute promyelocytic leukemia (APL), which, as described above, is often induced by a PML-RARa fusion oncogene (Lavau and Dejean, 1994; Figueroa et al., 2010; Iland and Seymour, 2013, Singh et al., 2018).