RUNX1T1 and leukemia: In the AML1-ETO fusion protein, the ETO domain aids in the recruitment of histone deacetylases (Yan et al., 2004; Liu et al., 2007), epigenetically driving the arrest of myeloid differentiation in t(8;21)-positive leukemia (Liu et al., 2007; Wichmann et al., 2015; Loke et al., 2017) and contributing to leukemogenesis (Liu et al., 2007; Loke et al., 2017).