HDAC8 and acute myeloid leukemia: HDAC8 expression is significantly enriched in inv(16) + AML cells compared to hematopoietic controls, and HDAC8 inhibition reduced inv(16) + AML cell viability, reducing cellular proliferation and inducing apoptosis in the AML cells while leaving control hematopoietic cells unaffected (Qi et al., 2015).