In epithelial tumors, this condition triggers the so-called angiogenic “switch” where the quiescent vascular network is induced to proliferate by the secretion of pro-angiogenic factors, such as VEGF (Vascular Endothelial Growth Factor) and FGF (Fibroblast Growth Factor) (Hida et al., 2018), allowing the formation of new vessels that penetrate into the tumor mass to supply oxygen and nutrients (Carmeliet and Jain, 2011). This evidence concerns the gene VEGFA and neoplasm.