RET and medullary thyroid gland carcinoma: For example, the multiple endocrine neoplasia type 2 (MEN2) syndrome, is characterized by different mutant-translocations involving the RET genes that result in multiple cancer phenotypes, including pheochromocytoma, parathyroid adenoma and the aggressive medullary thyroid carcinoma (MTC) (Das and Cagan, 2013).