The contribution of ATGL to cancer growth is controversial, indeed several studies showed that its depletion reduced proliferation in colorectal cancer cells and in non-small-cell lung carcinoma (Ou et al., 2014; Zagani et al., 2015), and in breast and pancreatic carcinoma its upregulation contributed to tumorigenesis (Grace et al., 2017; Wang et al., 2017). This evidence concerns the gene PNPLA2 and cancer.