This observation was also confirmed in glioblastomas where the human ortholog of brat, the tripartite motif-containing protein-3 (TRIM3), was shown to be necessary to suppress NOTCH1 signaling and to control stem cell activity during development to reduce tumor growth (Chen et al., 2014; Mukherjee et al., 2016). Here, TRIM3 is linked to glioblastoma.