Fbw7 is known to inhibit tumor growth by targeting proteins to the proteasome pathways, and is mutated in a wide range of primary human cancers, this data suggests that its role as a tumor suppressor may be conserved also in the modulation of HIF-regulated angiogenesis in the tracheal system of the fly (Mortimer and Moberg, 2013). The gene discussed is FBXW7; the disease is neoplasm.