Upstream, the Hippo cascade is regulated by components of cell junctions, including cell adhesion molecules such as Merlin, a homolog of the human Neurofibromatosis Type 2 (NF2) (Genevet et al., 2010; Yu et al., 2010), which acts as tumor suppressor; the cadherin Fat in complex with Dachsous; and by cell polarity regulators such as Crumbs (Robinson et al., 2010; Harvey et al., 2013). This evidence concerns the gene NF2 and neoplasm.