MMP1 and neoplasm: The last stage of tumorigenesis is represented by the invasive and metastatic capabilities of tumor cells to disrupt the apical-basal cell polarity, a process that is associated with the downregulation of cell-cell contact molecules and the release of metalloproteases (MMP1), lytic enzymes that degrade the extracellular matrix (ECM) allowing tumor cells to escape and colonize an environment that suites them and to acquire new oncogenic properties (Massague and Obenauf, 2016; Lambert et al., 2017).