Work using allograft transplantation experiments, identify also a function for the hemocytes in tumor initiation, that is independent on Eiger, but relays rather on the activation by external stimuli (i.e., CIN, abnormal growth) of JNK pathway and on the complex of non-autonomous and autonomous signals between tumor cells and those composing the tumor microenvironment; a similar mechanism has been proposed in vertebrates suggesting a conserved response for JNK signaling in fly to control initial tumor growth (Muzzopappa et al., 2017). This evidence concerns the gene MAPK8 and neoplasm.