Glioma stem cells divide asymmetrically under the guidance of cell polarity complexes that control the proper apical and basolateral polarization and cell division, a process that was originally identified in Drosophila and later confirmed for the mechanism driving differentiation in human glia for members of the Hugl-1/Llgl-1 complexes (Prehoda, 2009). The gene discussed is LLGL1; the disease is glioma.