These data connect the function of HUGL-1 in the maintenance of glioma stem cells with the loss of function of the tumor suppressor PTEN (Gont et al., 2013) and together with those in glioma (Read et al., 2009) show a conserved function for PI3K and EGFR overexpression in these tumors recapitulating many features of the neurogenic subtype of human glioblastoma. The gene discussed is EGFR; the disease is central nervous system cancer.