Apc mutant cells exhibit higher Yki/YAP activity and increased JNK signaling, that was also detected at the border between Apc−/− and wild-type cell; moreover, inhibition of apoptosis prevented Apc mutant cells from further expansion, suggesting that a competitive behavior in these cells is controlling Apc dependent tumor growth (Suijkerbuijk et al., 2016). This evidence concerns the gene APC and neoplasm.