CD4 and polyp: Consistently, we demonstrate that C26:0 long-term treatment of ApcMin/+ mice induced polyp expression of genes associated with pro-inflammatory immunity, including Ifng. After short-term treatment, there was an increased activation of CD4 and CD8 T cells in polyps, together with a systemic reduction of macrophages and increased proportion of the pro-inflammatory M1 macrophage phenotype.