ESRRA and experimental autoimmune encephalomyelitis: In this sense, the orphan nuclear hormone receptor, estrogen-related receptor-α (ERRα), is a key regulator that supports T cell functions, since the inhibition of ERRα decreased several glycolytic genes implicated in inflammatory cytokine production and T cell proliferation in an in vitro and in an experimental autoimmune encephalomyelitis mouse model, and a similar effect was found in ERRα-deficient T cells (143).