In a remarkable study, the non-solute transport role of NIS was delineated, where it was proved that there is an interaction of NIS with the leukemia-associated RhoA guanine exchange factor (LARG) leading to the activation of RhoA [Involvement of RhoA in breast cancer is discussed elsewhere (166)], which supports cell migration (167). This evidence concerns the gene SLC5A5 and breast carcinoma.