This observation is in line with studies by Savina et al. (56), who demonstrated NADPH oxidase influences the vacuolar pH, further supported in both MoDC and cDC2 when the oxidase was absent in CGD or inhibited by DPI, but further work is required to help understand the relationship between phagosomal pH and DC function. The gene discussed is FMO5; the disease is chronic granulomatous disease.