Specifically, early-life exposure to the obesogen BPA altered the expression of the genes encoding ER, NPY, POMC, and AgRP and decreased POMC fiber density in the paraventricular nucleus during adulthood, when offspring followed a high-fat diet, demonstrating that BPA can make them more vulnerable to manifesting diet-induced obesity and metabolic dysfunction (69). The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.