One of the latest meta-analyses that examined the association between vitamin D supplementation and systemic inflammation in patients with diabetes mellitus type 2 demonstrated that dietary cholecalciferol supplementation helps achieve a significant reduction in the activity of inflammation, and also confirmed the data showing that sufficient vitamin D levels help decrease C-reactive protein and TNF-alpha concentrations, decrease ESR, leptin concentrations (73). The gene discussed is LEP; the disease is diabetes mellitus.