IL1B and obesity due to melanocortin 4 receptor deficiency: The effect of vitamin D on inflammation in obesity is made up of the following components: In vitro, 1,25(OH)2D inhibits chronic inflammation resulting from obesity, the active metabolite of vitamin D 1,25 (OH) 2D inhibits the pro-inflammatory cytokines IL-1β, IL-6, IL-8, IL-12 (39–42, 44, 61), reduces inflammatory activity in adipocytes (62) and reduces inflammation in visceral adipose tissue, while not reducing in subcutaneous fat tissue (62, 63).