In listing the other oncogenes connected with amplifications in osteosarcoma, we need to mention Cell Division Cycle five-Like (CDC5L), Mitogen-Activated Protein Kinase 7 (MAPK7), Mesenchymal to Epithelial Transition (MET), PIM1, peripheral myelin protein 22 (PMP22), DNA Primase Subunit 1 (PRIM1) other than Runt Related Transcription Factor 2 (RUNX2), and Vascular endothelial growth factor A (VEGFA) (86). The gene discussed is RUNX2; the disease is osteosarcoma.