24 sALS vs. 24 HC: decreased uptake in premotor, motor, posterior association regions. 10 SOD1 D90A ALS vs. 24 HC: decreased uptake in left frontotemporal junction, anterior cingulate. 2 pre-symptomatic SOD1 D90A—decreased uptake in left frontotemporal junction. 4 PLS vs. HC: relative preservation of anterior and orbitofrontal binding compared to ALS. Here, SOD1 is linked to amyotrophic lateral sclerosis.