TRPV1 and cardiac hypertrophy: In contrast, another study showed that TRPV1 activation with capsaicin can antagonize high-salt diet-mediated cardiac hypertrophy, by ameliorating the mitochondrial complex I oxidative phosphorylation and suggesting that TRPV1-mediated amendment of mitochondrial dysfunction may represent a novel target for the management of early cardiac dysfunction (Lang et al., 2015).