TRPV2 and left ventricular hypertrophy: TRPV2 is also significantly upregulated in wild-type mice subjected to TAC, whereas the absence of functional TRPV2 reduces significantly the left ventricular hypertrophy after TAC, suggesting a role of TRPV2 in the development of cardiomyocyte hypertrophy because of an increased afterload (Koch et al., 2017).