Using animal models of pressure overload-induced heart hypertrophy, different studies demonstrated that TRPC1 (Ohba et al., 2007), TRPC3 (Bush et al., 2006; Brenner and Dolmetsch, 2007), and TRPC6 (Kuwahara et al., 2006) are upregulated in heart. The gene discussed is TRPC3; the disease is cardiac hypertrophy.