The deletion of the Trpm4 gene in 12-week-old mice was linked with moderate cardiac hypertrophy as well as ventricular dilation, increased cellular density, and reduced left ventricular cardiomyocytes size, suggesting that TRPM4 might act as a negative regulator of cardiomyocytes proliferation during prenatal development (Demion et al., 2014). Here, TRPM4 is linked to cardiac hypertrophy.