Indeed, inhibiting S1P signaling with FTY720 has protective effects when administered therapeutically in rodent models of MS (Sheridan and Dev, 2014), inflammatory arthritis (Matsuura et al., 2000; Wang et al., 2007; Tsunemi et al., 2010; Fujii et al., 2012; Han et al., 2015), and systemic lupus erythematosus (SLE) (Wenderfer et al., 2008). This evidence concerns the gene MBTPS1 and systemic lupus erythematosus.