Hence, EET-A reduced blood pressure in various forms of Ang II-dependent models of hypertension in rats (Neckář et al., 2012; Hye Khan et al., 2014; Červenka et al., 2018) and in mice with high fat diet-induced obesity (Singh et al., 2016). This evidence concerns the gene AGT and obesity due to melanocortin 4 receptor deficiency.