Indeed, it has been reported that other sEH inhibitors such as AEPU, AUDA and TPPU reduced the development of cardiac hypertrophy and diminished adverse cardiac remodeling in normotensive mice subjected to pressure overload due to thoracic aortic constriction (Xu et al., 2006; Sirish et al., 2013). The gene discussed is EPHX2; the disease is cardiac hypertrophy.