Therefore, here we examined the effect of EET-A (a third generation of EET analog with better water solubility and improved oral bioavailability) and c-AUCB (sEH inhibitor), given alone or combined, on the progression of post-MI CHF in normotensive Hannover Sprague-Dawley (HanSD) and in heterozygous Ren-2 transgenic rats (TGR) with angiotensin II (Ang II)-dependent form of hypertension. The gene discussed is EPHX2; the disease is congestive heart failure.