Numerous studies reported that a change of mitochondrial function plays a key role in all kinds of cancers (Tao et al., 2015; Lin et al., 2017b; Zhang J.Y. et al., 2017; Zhang J. et al., 2017), and RBPs involved in the expression and transcription regulation of mitochondrial genes, such as LRPPRC, GRSF1, SLIRP, and other RBPs can interact with mt-RNA to affect the expression and metabolism of mitochondrial transcripts (Dong et al., 2017). This evidence concerns the gene GRSF1 and cancer.