For instance, upregulation of GLT1 expression improves signs of Huntington’s disease in symptomatic R6/2 mice (Miller et al., 2008) and enhanced GLT1 expression also has been detected in the prefrontal cortex of schizophrenic patients, suggesting impaired glutamatergic transmission in this disease (Matute et al., 2005). The gene discussed is SLC1A2; the disease is Huntington disease.