As the best-characterized inflammasome, studies found that NLRP3 was activated in AD (Saresella et al., 2016), which can be activated by cholesterol, cathepsin and also by the amyloid peptide (Duewell et al., 2010; Masters and O’Neill, 2011; Jo et al., 2016). This evidence concerns the gene NLRP3 and Alzheimer disease.