In animal and cell culture studies dysregulation of PI3K, Akt, and mTOR (Rodon et al., 2013) was led to tumor formation, while knocking out of PI3K, Akt, or mTOR, blocked this oncogenic transformation (Liu et al., 2009), inhibited tumor growth and blocked its invasiveness (Cheng et al., 2005; Slomovitz and Coleman, 2012; Statz et al., 2017). The gene discussed is AKT1; the disease is neoplasm.