AKT1 and Alzheimer disease: The repetitive metabolic stress is a shared phenomenon for both AD and cancer (Moreira et al., 2010; Morgen and Frolich, 2015; Sun et al., 2016; Zhao et al., 2017), which could trigger PI3K/Akt/mTOR activation, cell cycle re-entry and autophagy inhibition, the other three shared features between AD and cancer.