An example is involvement of phosphoinositide 3 kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway, an essential axis in cell proliferation, metabolism, growth and autophagy in pathogenesis of AD and cancer (Pei and Hugon, 2008; Morgan et al., 2009; Advani, 2010; Talbot et al., 2012; Fumarola et al., 2014; Porta et al., 2014). The gene discussed is AKT1; the disease is Alzheimer disease.