MAPT and Alzheimer disease: Increase in Aβ deposition (Chen et al., 2009; Cai et al., 2012), decrease its clearance (Pei and Hugon, 2008; Cai et al., 2012), disrupted clearance of tau and the consequent synaptic loss and cognitive decline in AD, all could occur as the result of PI3K/Akt/mTOR activation (Ma et al., 2011; Graziotto et al., 2012; O’Neill, 2013; Yang et al., 2013).