MIF and Down syndrome: Figure 2 also shows that the pattern of MIF concentrations in controls and patient groups according to the CPSI genotypes did not seem to be influenced by the presence or absence of Down syndrome, acknowledging that there was a restricted power for subgroup analyses.  Figure 3 shows the levels of the MIF chemokine when the two factors (clinical/hemodynamic profile and CPSI T1405N genotypes) were analyzed in combination.