MAPT and Alzheimer disease: We found that DHED which is a brain-selective prodrug of 17β-estradiol and produces the hormone only in the brain could improve the memory deficits in Tg2576 transgenic AD model and could decrease Aβ and phosphorylated tau protein levels in the brain of ovariectomized female AD mice (Merchenthaler et al. 2016; Prokai et al. 2015).