Indeed, the diet used in the present study has been shown to induce severe impairments of glucose tolerance but also non-alcoholic steatohepatitis associated with a marked induction of proinflammatory cytokines such as tumor necrosis factor α and interleukin 6 both shown to attenuate the induction of Adipoq mRNA in adipocytes (for overview see [53]). Here, IL6 is linked to metabolic dysfunction-associated steatohepatitis.