SERPINE1 and polycystic ovary syndrome: This disparity in plasminogen expression between PCOS and control ovaries, combined with differential PAI-1 ovarian localisation and expression within developing follicles in the 2 experimental models, as was noted earlier, may be induced by the androgen (DHT) excess in the PCOS model versus that of controls, and suggests androgens may be involved, at least in part, in regulating expression of ovarian fibrinolytic/proteolytic markers and the ovarian plasminogen system.