The differential expression of PAI-1 and plasminogen only in PCOS and control ovaries as well as observations of differential PAI-1 patterns as follicles develop may indicate potential differences in proteolytic actions/levels of these markers and further support our earlier conclusions of a possible disparity in underlying causes or effects between ovarian physiological and pathological (PCOS) states. The gene discussed is SERPINE1; the disease is polycystic ovary syndrome.