Atiomo et al found that PAI-1 was expressed in both the granulosa and theca cell compartments of PCOS and non-PCOS human ovaries and while there was overall more PAI-1 detected around the follicles of polycystic ovaries this did not reach statistical significance when compared to control ovaries [16]. The gene discussed is SERPINE1; the disease is polycystic ovary syndrome.