SERPINE1 and polycystic ovary syndrome: Overall, we did not observe any significant difference in the staining for PAI-1, tPA, uPA, plasminogen/plasmin or plasminogen evaluated for either mean total area of IHC staining (Sum Area), percentage of staining (Area Fraction ROI) or average intensity of staining (Mean Colour Intensity Value) of whole ovaries between PCOS and controls (Table 2; p > 0.05).