Similar to ClpP, we observed a significant decrease in the protein levels of SOD2 in both αSyn A53T PD patient iPS cells (Suppl Fig. 5a) and neuronal cells derived from PD patient iPS cells carry αSyn A53T (Fig. 4a), and in the midbrain containing the SN of αSyn A53T mice starting from the age of 8 months (Fig. 4b). The gene discussed is SOD2; the disease is Parkinson disease.