Indeed, evaluation of a variety of cancer-bearing murine models (i.e., human breast cancer, colon cancer, and a syngeneic metastatic colon cancer and melanoma mouse model) demonstrated that TRAIL-conjugated PMDV-Si particles were able to efficiently target CTCs in lung vasculature and to dramatically decrease lung metastases compared to untreated mice, empty PMDV-coated Si particles, and soluble TRAIL. This evidence concerns the gene TNFSF10 and breast carcinoma.