METTL3 and nonpapillary renal cell carcinoma: Similar as our results, a recent study showed knockdown of METTL3 in ccRCC cell lines led to obvious upregulation of PI3k, AKT and mTOR expression and patients with positive METTL3 expression had obviously longer survival time than those with negative METTL3 expression [26], implying that the mRNAs of molecules in mTOR pathway may be the target mRNA of m6A modification.