In addition, the “writers” METTL3 and METTL14 were more predisposed to mutation or CNV than the other genes in ccRCC, while alterations of the “erasers” FTO and ALKBH5 were proved to be more important in breast cancer, glioblastoma and hematological malignancies [21,28,29]. Here, METTL3 is linked to glioblastoma.