To address this, we performed genetic manipulation studies in murine haematopoietic progenitor cell lines harbouring either wild-type C/EBPα or the most frequently occurring combinations of biallelic CEBPA mutations, that is Nter/Nter or Nter/Cter to determine the biological and molecular consequences of reduced Myb activity on the leukaemia driven by those mutations. This evidence concerns the gene CEBPA and leukemia.